Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells
نویسندگان
چکیده
منابع مشابه
Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells
BACKGROUND Omalizumab, is a humanized anti-IgE monoclonal antibody used to treat allergic asthma. Decreased serum IgE levels, lower eosinophil and B cell counts have been noted as a result of treatment. In vitro studies and animal models support the hypothesis that omalizumab inhibits IgE synthesis by B cells and causes elimination of IgE-expressing cells either by induction of apoptosis or ind...
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Results Omalizumab (10 ug/mL) inhibited IgE binding to LAD2 cells by 78% (P=0.007) compared to untreated control. Omalizumab (10 ug/mL) further blocked IgE-dependent upregulation of FcεRI expression by 90% (P=0.03). In addition, omalizumab removed FcεRI-bound IgE in a time-dependent manner; an effect that was detected as early as 24 hrs (57% removal; P<0.001) after addition of omalizumab result...
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ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2013
ISSN: 2045-7022,2045-7022
DOI: 10.1186/2045-7022-3-29